im interesting in additionally suppressing HPG axis without super high E(can cause mood swings)
what other benefits of prog?
im worried about converting into DHT in liver via oral route(i dont like rectal method…)
im interesting in additionally suppressing HPG axis without super high E(can cause mood swings)
what other benefits of prog?
im worried about converting into DHT in liver via oral route(i dont like rectal method…)
If you’re only going to take it orally, don’t bother tbh - it probably won’t help you much at all.
I took it for the reason you mentioned - to help suppress testosterone production, and then to help me sleep when my E levels were high when I was using monotherapy to suppress T.
But I only took it rectally, and I only recommend you take it rectally. There’s not much point in taking it orally.
is possible to take prog sublingualy?
or transdermal, progestogel
The article I linked to covers this:
https://transfemscience.org/articles/oral-p4-low-levels/
the t;dl answer is basically no - rectal administration is really the best option.
It’s not really a big deal tbh, plenty of medications are administered rectally (or vaginally).
here’s the longer answer:
for sublingual there are two problems:
so:
1. though it raises the blood progesterone levels much better than oral route, the metabolism is too spikey so you don’t really benefit from consistently elevated blood progesterone levels, making it somewhat pointless (this is a similar problem with sublingual estrogen)
2. sublingual progesterone is not available for most people, very few will have access to it
The problem with transdermal is that progesterone does not absorb through the skin well, so it doesn’t raise blood progesterone levels sufficiently, it’s similarly low as oral route:
so again, not an option.
The real alternative to rectal is daily injections - which is again impractical not just from a cost perspective, but because injectable progesterone is not widely available.
This is why rectal administration is basically the only reasonable route of administration for progesterone.
so progestogel can be used only for breasts growth?
As already mentioned, progestogel, just like oral progesterone, does not sufficiently raise blood progesterone levels. The conclusion is not that progestogel can only be used for breast growth, but instead that it won’t successfully help a transfeminine individual raise their blood progesterone to be similar to cis female levels, making it an insufficient route of administration.
It won’t work, don’t take it - it’s a waste of money and time.
Realistically the only option is rectal administration of oral progesterone pills.