One interspecies variation in the anatomical location of the CB1 receptors is found in dogs. As compared to humans, studies have determined the number of CB1 receptors in hind brain structures in the dog to far exceed those found in the human animal. The US government conducted studies that determined that dogs have large numbers of cannabinoid receptors in the cerebellum, brain stem, and medulla oblongata [22]. “Static ataxia,” which is a unique neurological reaction to THC in the dog, is explained by this high concentration of CB receptors in the cerebellum. Static ataxia was first described in 1899 by Dixon in his pharmacologic study of Indian Hemp (High THC cannabis) in a variety of species, including human [23]. Other locations for Cannabinoid receptor 1 include the peripheral nervous system, as well as cardiovascular, immune, gastrointestinal, and reproductive tissues. Cannabinoid receptor 2 has been found mainly in cells of the immune system and the spleen and tonsils [24]. The CB1 and CB2 receptors are structurally quite similar, despite their different anatomical locations in the central nervous and immune systems, respectively.

Don’t give your dogs THC.